Institut Pasteur of Shanghai, Chinese Academy of Sciences (IPS-CAS) is a legally independent, non-profit life sciences institute that addresses public health issues in China and the Asian region (http://english.shanghaipasteur.cas.cn/). IPS-CAS conducts research and early stage development in infectious diseases with an unmet medical need in the fields of diagnostics, therapeutics and vaccines. IPS-CAS has a large panel of core facilities and excellent working conditions in a highly collaborative environment and in strong connection with the Chinese Academy of Sciences and Pasteur institute networks. IPS-CAS now announces the following positions available for postdoctoral research fellow. Applicants are encouraged to apply for the support of MARIE CURIE INTERNATIONAL OUTGOING FELLOWSHIPS.
Call identifier: FP7-PEOPLE-2012-IOF
Date of publication: 13 March 2012
Deadline: 16 August 2012 at 17:00, Brussels local time
1. Unit of Anti-infection Research The Unit of Anti-infection Research directed by Professor Ralf Altmeyer focuses on anti-viral drug discovery against EV71 (Hand Foot and Mouth Disease), RSV and Parainfluenza Viruses. The researchers of the Unit use a chemical genetics approach based on libraries of approved drugs and probe compounds with known targets to identify cellular targets and pathways involved in viral replication. In collaboration with the Children Hospital of Fudan University we conduct clinical research activities including genetic susceptibility to severe HFMD (neurological complications) and molecular epidemiology of EV71.
Requirements: 1. Applicants should hold a Ph.D. degree and a publication record in peer-reviewed international journals. 2. IPS-CAS will assist the qualified applicants to apply for International Outgoing Fellowship supported by European Commission.
Applicants should email his/her full curriculum vitae and a brief letter of motivation and provide email and phone numbers of at least two references to gangzou@ips.ac.cn.
2. Unit of Antiviral Immunity and Genetic Therapy Two postdoctoral Research Scientist positions are available at the Unit of Antiviral Immunity and Genetic Therapy for researches in HIV and influenza viruses. On-going work in HIV focuses on development of GPI-anchored antibody derivative strategy for identification of novel broad neutralization epitopes on HIV spikes as well as on development of virus like particles as major vaccine components in heterologous prime-boost strategy (Wen et al. Retrovirology 2010; Liu et al. Journal of Virology 2011; Yang et al. Journal of Virology 2012). On-going work in influenza viruses focuses on development of “universal” immunogens against HPAI H5N1 viruses and beyond (Ding et al. PLoS ONE 2011a; Ding et al. PLoS ONE 2011b; Hu et al. Journal of Virology 2012; Zhou et al. Journal of Virology 2012). Candidates should have M.D. and/or Ph.D. degree with experience in one of following areas: molecular and cellular biology, immunology and virology. It is preferable for candidates with European Union International fellowship. Please send resume and names of three references to Dr. Paul Zhou at e-mail: blzhou@sibs.ac.cn.
3. Unit of Molecular Immunology
We seek highly motivated individuals for several postdoctoral fellow positions in the Unit of Molecular Immunology.
We study the cellular and molecular mechanisms regulating the immune response in major human infectious diseases. Currently, we are particularly interested in understanding the dynamic role of a subpopulation of T cells, namely natural or inducible regulatory T cells (FOXP3+Tregs), in major human infectious diseases (Background reading: Li B et al. 2006 Immunol. Rev. 212:99-113; Li B et al. 2007 Curr. Opin. Immunol. 19 (5):589-95; Li and Greene 2007 Cell Cycle 15;6 (12):1432-6; Li and Greene 2008 Immunology 123 (1):17-9; Xiao Y, Li B et al 2010 Curr. Opin. Immunol. 22 (5):583-91, Gao YY et al 2012 Genes Immun. 13(1):1-13).
For more information in English and in Chinese. Applicants should hold a Ph.D. degree in virology, immunology, cellular biology or clinical research, with research background in the following fields: clinical immunology, HIV, HCV or Flu infection, microRNA biology, cell metabolism, or in vivo disease models will be a plus. Individuals who are interested in studying the regulatory role of the immune system in major infectious diseases or viral-host interactions are encouraged to apply. Please submit research statement, curriculum vitae, and names/e-mail addresses of three referees directly to binli@sibs.ac.cn. General enquiries are welcome. Positions will remain open until filled. Salary will be commensurate with experience.
4. Unit of Viral Hepatitis A post-doctoral position is now available in Dr. Jin Zhong’s laboratory (Unit of Viral Hepatitis). The available projects include: to study how HCV induces and evades host innate immune responses; to study molecular mechanisms underlying HCV assembly and egress. Highly motivated individuals who are interested in studying other aspects of HCV are also encouraged to apply. A Ph.D. degree in biomedical science is required, preferably in virology, immunology, molecular biology and biochemistry. Candidates need to have a fellowship to cover their salary, and the research cost will be provided by the lab. Please contact Dr. Jin Zhong at jzhong@sibs.ac.cn before you submit an official application. The detailed information of the lab can be found at the following webpage.
5. Unit of Herpesvirus and Molecular Virology Research We are seeking highly motivated individual for postdoctoral position in the laboratory of Herpesvirus and molecular virology research. The objective of our research is to dissect the role of the unfolded protein response during cytomegalovirus infection, of particular interest in its cross talk with inflammation and innate immunity. Please click here for more information. Applicants should have a Ph.D degree in Molecular Biology, Virology, or related fields. Salary will be commensurate with qualification and experiences. Please submit research statement, curriculum vitae, names and e-mail addresses of three references to zkqian@ips.ac.cn.
6. Team of “Emerging Bacterial Pathogen” directed by Prof. Brigitte Gicquel
The arising of multiple antibiotic resistances is a growing concern for the treatment of mycobacterial infectious diseases including tuberculosis. Mycobacteria share similarities at the cell wall level and show antibiotic resistances due to pathways inhibiting bacterial killing by antibiotics in addition to resistances acquired by acquisition of chromosomal mutations in antibiotic target genes. The proposed project aims at using a series of transposon mutant libraries of bacterial species easy to manipulate (fast growing species closely related to pathogenic species but not harmful for non immune-compromised individuals) for the isolation of mutants with increased susceptibility to antibiotics that are used in clinic and molecules issued from Research and Development projects with antibacterial activity.
Because species have developed different mechanisms of natural escape to bacterial killing, the screening of mutant libraries of different species will identify antibiotic resistance mechanisms not previously identified using single species for screening. This approach will allow the identification of new pathways playing a role in the biology of the bacterial species included in the study together with the identification of new drugs inhibiting these pathways. Such an approach might identify new drugs that will be used in combination with drugs already used and improve the therapeutic regimen by lowering concentrations to be used or shorten the duration of the treatment to optimise antibacterial activity and lower side effects. This is extremely important for diseases like tuberculosis requiring at least a six-month treatment with several antibiotics for non MDR strains and more than one year with an increased number of antibiotics for MDR strains.
The proposed project will be developed in collaboration with the team of Brigitte Gicquel at the Institut Pasteur in Paris (Visiting Professor at IPS-CAS) and the team of Qian Gao at the Fudan University in Shanghai. These teams have a long lasting collaboration and have developed genetic tools and constructed representative libraries of mutants of M. tuberculosis, M. smegmatis, and M. marinum. Robots for replicating and screening the libraries will be available at the Institut Pasteur of Shanghai together with DNA sequencing and bioinformatics facilities. The post doc fellow should have expertise in bacterial genetics and molecular biology. He/She should be able to develop the project with some independence.
The applicant should apply to the Marie Curie Programme for financial support.
Contact: brigitte.gicquel@pasteur.fr
7. Team of Filamentous Fungus(F2)
The newly created Filamentous Fungus(F2) team (Prof Jean-Paul Latge) at the Institut Pasteur of Shanghai is focused on the pathobiology of Aspergillus and other filamentous fungi. Human fungal infections currently represent 15% of the total of hospital-acquired infections. Although fungal infections are the least publicized agents of human diseases, they are to date often responsible for a higher mortality than bacterial infections.
The F2 laboratory is searching for 3 post doctoral Research Associate positions for 3 years starting October 2012.
This person will work in a group composed of molecular biologists, protein chemists and should be ready to be involved in international collaborations with other laboratories world wide. The F2 research unit will have especially an active collaboration with the Aspergillus unit of the Institut Pasteur in Paris which is also headed by Prof. Jean-Paul Latgé.
Description of the function:
Post Doct 1- The post-project is focused on the identification of genes specifically expressed and controlling the response of Aspergillus fumigatus to stress (in vitro and in vivo) using RNA seq technologies, deletion of the genes of interest and phenotypic response of the mutants in vivo and in vitro.
Requirements: We are looking for candidates with a PhD and extensive experience in molecular biology (and genomics) of filamentous fungi (Aspergillus). Experience in Microbiology or biochemistry or immunology will also be especially appreciated. A post doctoral position abroad will be welcome for this position.
Post Doct 2- The post is focused on the analysis of Aspergillus cell wall permeability to drugs and toxic metabolites. The respective role of mutations in the drug target, activation of efflux pumps and epigenetic events in the resistance to drugs will be analysed using a systems biology approach.
Requirements: We are looking for candidates with a PhD and extensive experience in molecular biology (and genomics) of Saccharomyces cerevisiae that is also willing to work with filamentous fungi. Experience in biochemistry will also be especially appreciated. A post doctoral position abroad will be welcome for this position. Post Doct 3- The impact of fungal secreted molecules produced in complex microbial community on the immune response of the host will be analysed as well as the role of toxic host response molecules on fungal quiescence/persistence in vivo.
Requirements: We are looking for candidates with a PhD and extensive experience in microbial immunology. Experience in filamentous fungi (Aspergillus) and biochemistry will be especially appreciated. A post doctoral position abroad will be welcome for this position. Interested? Please send your application including curriculum vitae and contact details of three potential references to Prof. JP Latge jean-paul.latge@pasteur.fr Duration: 3 years (renewable), available starting October, 2012. Salary: Salary scale negotiable, depending on age and experience Location: Institut Pasteur of Shangai (China) Information: For additional information please contact JP Latge jean-paul.latge@pasteur.fr
