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Publications

2020

Saeed Behzadinasab, Alex Chin, Mohsen Hosseini, Leo L. M. Poon, William A. Ducker

A Surface Coating that Rapidly Inactivates SARS-CoV-2

ACS Appl. Mater. Interfaces 2020 ; doi.org/10.1021/acsami.0c11425

Thomas H. C. Sit, Christopher J. Brackman, Sin Ming Ip, Karina W. S. Tam, Pierra Y. T. Law, Esther M. W. To, Veronica Y. T. Yu, Leslie D. Sims, Dominic N. C. Tsang, Daniel K. W. Chu, Ranawaka A. P. M. Perera, Leo L. M. Poon & Malik Peiris

Infection of dogs with SARS-CoV-2

doi.org/10.1038/s41586-020-2334-5

Asmaa Hachim, Niloufar Kavian, Carolyn A Cohen, Alex WH Chin, Daniel KW Chu, Chris Ka Pun Mok, Owen TY Tsang, Yiu Cheong Yeung, Ranawaka APM Perera, Leo LM Poon, Malik JS Peiris, Sophie A Valkenburg

Beyond the Spike: identification of viral targets of the antibody response to SARS-CoV-2 in COVID-19 patients

doi: https://doi.org/10.1101/2020.04.30.20085670

Alex W H Chin, Julie T S Chu, Mahen R A Perera, Kenrie P Y Hui, Hui-Ling Yen, Michael C W Chan, Malik Peiris, Leo L M Poon

Stability of SARS-CoV-2 in different environmental conditions

doi.org/10.1016/ S2666-5247(20)30003-3

Yuan M, Wu NC, Zhu X, Lee CCD, So RTY, Lv H, Mok CKP, Wilson IA

A highly conserved cryptic epitope in the receptor-binding 4 domains of SARS-CoV-2 and SARS-CoV

Science, in press; bioRxiv doi/10.1101/2020.03.13.991570.

Wang Y, Li X, Liu W, Gan M, Zhang L, Wang J, Zhang Z, Zhu A, Li F, Sun J, Zhang G, Zhuang Z, Luo J, Chen D, Qiu S, Zhang L, Xu D, Mok CKP, Zhang F, Zhao J, Zhou R, Zhao J

Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018

Emerg Microbes Infect 9:246-255.

Arunachalam PS, Wimmers F, Mok CKP, Perera M, Scott M, Hagan T, Sigal N, Feng Y, Bristow L, Tsang OTY, Wagh D, Coller J, Pellegrini KL, Alaaeddine G, Leung WS, Chan JMC, Chik TSH, Choi CYC, Huerta C, McCullough MP, Lv H, Anderson E, Edupuganti S, Upadhyay AA, Bosinger SE, Maecker HT, Khatri P, Rouphael N, Peiris M, Pulendran B (2020)

Systems biological assessment of immunity to severe and mild COVID-19 infections

Science 369:1210-1220.

Carreño JM, McDonald JU, Hurst T, Rigsby P, Atkinson E, Charles L, Nachbagauer R, Behzadi MA, Strohmeier S, Coughlan L, Aydillo T, Brandenburg B, García-Sastre A, Kaszas K, Levine MZ, Manenti A, McDermott AB, Montomoli E, Muchene L, Narpala SR, Perera RAPM, Salisch NC, Valkenburg SA, Zhou F, Engelhardt OG, Krammer F (2020)

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies.

Vaccines (Basel) 8:E666.

Chan PKS, Lui G, Hachim A, Ko RLW, Boon SS, Li T, Kavian N, Luk F, Chen Z, Yau EM, Chan KH, Tsang CH, Cheng SMS, Chu DKW, Perera RAPM, Ho WCS, Yeung ACM, Chow C, Poon LLM, Valkenburg SA, Hui DSC, Peiris M (2020)

Serologic responses in healthy adult with SARS-CoV-2 reinfection, Hong Kong, August 2020.

Emerg Infect Dis, in press.

Choi EM, Chu DKW, Cheng PKC, Tsang DNC, Peiris M, Bausch DG, Poon LLM, Watson-Jones D (2020)

In-flight transmission of severe acute respiratory syndrome coronavirus 2.

Emerg Infect Dis 26:2713-2716.

Chu DKW, Pan Y, Cheng SMS, Hui KPY, Krishnan P, Liu Y, Ng DYM, Wan CKC, Yang P, Wang Q, Peiris M, Poon LLM(2020)

Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia.

Clin Chem 66:549-555.

Drall KM, Field CJ, Haqq AM, de Souza RJ, Tun HM, Morales-Lizcano NP, Konya TB, Guttman DS, Azad MB, Becker AB, Lefebvre DL, Mandhane PJ, Moraes TJ, Sears MR, Turvey SE, Subbarao P, Scott JA, Kozyrskyj AL (2020)

Vitamin D supplementation in pregnancy and early infancy in relation to gut microbiota composition and C. difficilecolonization: implications for viral respiratory infections.

Gut Microbes 12:1799734.

Hemida MG, Chu DKW, Chor YY, Cheng SMS, Poon LLM, Alnaeem A, Peiris M (2020)

Phylogenetic Analysis of MERS-CoV in a Camel Abattoir, Saudi Arabia, 2016-2018.

Emerg Infect Dis 26:3089-3091.

ISARIC clinical characterisation group* (2020) 

Global outbreak research: Harmony, not hegemony.

Lancet Infect Dis 20:770-772.

Kavian N, Hachim A, Wang Y, Poon LLM, Valkenburg SA (2020)

Vaccination with ADCC activating HA peptide epitopes provides partial protection from influenza infection.

Vaccine 38:5885-5890.

Lau YC, Perera RAPM, Fang VJ, Luk LH, Chu DKW, Wu P, Barr IG, Peiris JSM, Cowling BJ (2020)

Variation by lineage in serum antibody responses to influenza B virus infections.

PLoS One 15:e0241693.

Li MY, Naik TS, Siu LYS, Acuto O, Spooner E, Wang P, Yang X, Lin Y, Bruzzone R, Ashour J, Evans M, Sanyal S (2020)

Lyn kinase regulates egress of flaviviruses in secretory autophagosomes.

Nat Commun 11:5189.

Liu ZL, Liu Y, Wan LG, Xiang TX, Le AP, Liu P, Peiris M, Poon LLM, Zhang W (2020)

Antibody profiles in mild and severe cases of COVID-19.

Clin Chem 66:1102-1104.

Nielsen CC, Gascon M, Osornio-Vargas AR, Shier C, Guttman DS, Becker AB, Azad MB, Sears MR, Lefebvre DL, Moraes TJ, Turvey SE, Subbarao P, Takaro TK, Brook JR, Scott JA, Mandhane PJ, Tun HM, Kozyrskyj AL (2020)

Natural environments in the urban context and gut microbiota in infants.

Environ Int 142:105881.

Peng Y, Tan Q, Afhami S, Deehan EC, Liang S, Gantz M, Triador L, Madsen KL, Walter J, Tun HM, Haqq AM (2020)

The Gut Microbiota Profile in Children with Prader-Willi Syndrome.

Genes (Basel) 11:904.

Perera RAPM, Ko R, Tsang OTY, Hui DSC, Kwan MYM, Brackman CJ, To EMW, Yen HL, Leung K, Cheng SMS, Chan KH, Chan KCK, Li KC, Saif L, Barrs VR, Wu JT, Sit THC, Poon LLM, Peiris M (2020)

Evaluation of a SARS-CoV-2 surrogate virus neutralization test for detection of antibody in human, canine, cat and hamster sera.

J Clin Microbiol, in press.

Perera RAP, Mok CKP, Tsang OTY, Lv H, Ko RLW, Wu NC, Yuan M, Leung WS, Chan JMC, Chik TSH, Choi CYC, Leung K, Chan KH, Chan KCK, Li KC, Wu JT, Wilson IA, Monto AS, Poon LLM, Peiris M (2020)

Serological assays for SARS-CoV-2.

Eurosurveill 25:pii=2000421.

Perera RAPM, Tso E, Tsang OTY, Tsang DNC, Fung K, Leung YWY, Chin AWH, Chu DKW, Cheng SMS, Poon LLM, Chuang VWM, Peiris M (2020)

SARS-CoV-2 Virus Culture and Subgenomic RNA for Respiratory Specimens from Patients with Mild Coronavirus Disease.

Emerg Infect Dis 26:2701-2704.

Poon LLM, Peiris M (2020)

Emergence of a novel human coronavirus threatening human health.

Nat Med 26:317-319.

Tan Q, Orsso CE, Deehan EC, Triador L, Field CJ, Tun HM, Han JC, Müller TD, Haqq AM (2020)

Current and emerging therapies for managing hyperphagia and obesity in Prader-Willi syndrome: A narrative review.

Obes Rev 21:e12992.

Wang Y, Sun J, Li X, Zhu A, Guan W, Sun DQ, Gan M, Niu X, Dai J, Zhang L, Zhang Z, Shi Y, Huang S, Mok CKP, Yang Z, Wang Z, Tan W, Li Y, Chen L, Chen R, Peiris M, Zhong N, Zhao J, Huang J, Zhao J (2020)

Increased Pathogenicity and Virulence of Virus in Middle East Respiratory Syndrome Coronavirus Clade B in Vitro and in Vivo.

J Virol 94:e00861-20.

Wang Y, Zhang L, Sang L, Ye F, Ruan S, Zhong B, Song T, Alshukairi AN, Chen R, Zhang Z, Gan M, Zhu A, Huang Y, Luo L, Mok CKP, Al Gethamy MM, Tan H, Li Z, Huang X, Li F, Sun J, Zhang Y, Wen L, Li Y, Chen Z, Zhuang Z, Zhuo J, Chen C, Kuang L, Wang J, Lv H, Jiang Y, Li M, Lin Y, Deng Y, Tang L, Liang J, Huang J, Perlman S, Zhong N, Zhao J, Peiris JSM, Li Y, Zhao J (2020)

Kinetics of viral load and antibody response in relation to COVID-19 severity.

J Clin Invest 130:5235-5244.

Wong HH, Sanyal S (2020)

Viral strategies of manipulating autophagy to benefit infection.

Semin Cell Dev Biol 101:3-11.

Zhang J, Lan Y, Sanyal S (2020)

Membrane heist: Coronavirus host membrane remodeling during replication.

Biochimie 179:229-236.

Zhang M, Wang X, Yang X, Dong T, Hu W, Guan Q, Tun HM, Chen Y, Chen R, Sun Z, Chen T, Xia Y (2020)

Increased risk of gestational diabetes mellitus in women with higher prepregnancy ambient PM2.5 exposure.

Sci Total Environ 730:138982.

Assessment of enhanced influenza vaccination finds FluAd advantage in mice and older adults

Kavian N, Hachim A, Li APY, Cohen CA, Chin AHW, Poon LLM, Fang VJ, Leung NHL, Cowling BJ, Valkenburg SA

Clin Transl Immunol 9:e1107.

Cowling BJ, Perera RAPM, Valkenburg SA, Leung NHL, Iuliano AD, Tam YH, Wong JHF, Fang VJ, Li APY, So HC, Ip DKM, Azziz-Baumgartner E, Fry AM, Levine MZ, Gangappa S, Sambhara S, Barr IG, Skowronski DM, Peiris JSM, Thompson MG

Comparative immunogenicity of several enhanced influenza vaccine options for older adults: A randomized, controlled trial

Clin Infect Dis doi: 10.1093/cid/ciz1034. PMID: 31828291.

Jahan AS, Biquand E, Munoz-Moreno R, Le Quang A, Mok CK, Wong HH, Teo Q, Valkenburg SA, Chin AWH, Poon LLM, te Velthuis A, García-Sastre A, Demeret C, Sanyal S

OTUB1 is a key regulator of RIG-I-dependent immune signaling and is targeted for proteasomal degradation by influenza A NS1

Cell Rep 30:1570–1584.

Lv H, Wu NC, Tsang OT, Yuan M, Perera RAP, Leung WS, So RT, Chan JMC, Yip GK, Chik TSH, Wang Y, Choi CYC, Lin Y, Ng WW, Zhao J, Poon LLM, Peiris JSM, Wilson IA, Mok CKP

Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

Cell Rep, doi: https://doi.org/10.1101/2020.03.15.993097.

Li MY, Naik TS, Siu LYS, Acuto O, Spooner E, Wang P, Yang X, Lin Y, Bruzzone R, Ashour J, Sanyal S

Activation of Src-family kinases orchestrate secretion of flaviviruses by targeting mature progeny virions to secretory autophagosomes

Nat Microbiol, in revision; bioRxiv doi: https://doi.org/10.1101/2020.01.12.903062

Turning influenza vaccinology on its head to reveal the stalk

Valkenburg SA, Cowling BJ

Lancet Infect Dis 20:5-7.

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